Guy Park State Historic Site is a house built in 1774 in the Georgian architectural style for Guy Johnson, the Irish-born nephew and son-in-law to Sir William Johnson, 1st Baronet, the British Superintendent for Indian Affairs in colonial New York. Built of limestone, the house was originally situated on a square mile of land on the north side of the Mohawk River and near it for access to water transportation.

Guy Park was used for years in the early nineteenth century as a tavern and stagecoach stop, as it was on the Mohawk Turnpike next to the river, the two main transportation routes across the state. The Erie Canal was completed in 1825, and a lock is located near the house. Later, the house was sold and served again as a private residence for many years.

In 1907 the mansion was purchased by the state for preservation as a historic site. In the early 21st century, it was adapted for use as a local history museum, the Walter Elwood Museum. It was added to the National Register of Historic Places in 1973.

In August 2011, shortly after being occupied by the museum, the house was severely damaged by flooding of the Mohawk River in the aftermath of Hurricane Irene. Half of two floors were destroyed and contents soaked and scattered. The state canal corporation has struggled to stabilize the building. The museum has moved to a new location and future uses of the building are unclear.